Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy.

doi:10.1186/s13046-019-1458-7

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Article

Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy.

Journal of experimental & clinical cancer research : CR - 1 Nov 2019

Silkenstedt Elisabeth, Arenas Fabian, Colom-Sanmartí Berta, Xargay-Torrent Sílvia, Higashi Morihiro, Giró Ariadna, Rodriguez Vanina, Fuentes Patricia, Aulitzky Walter E, van der Kuip Heiko, Beà Sílvia, Toribio Maria L, Campo Elias, López-Guerra Mònica, Colomer Dolors

Abstract excerpt

BACKGROUND: NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5-10% of cases and are associated with significantly shorter survival rates. The present study aimed to investigate the biological impact of this mutation in MCL and its potential as a therapeutic target. METHODS: Activation of Notch1 signaling upon ligand-stimulation and inhibitory effects of the monoclonal anti-Notch1...

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Identifiers

PMID: 31676012
DOI: 10.1186/s13046-019-1458-7
PMCID: PMC6825347

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