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Article

MutSβ exceeds MutSα in dinucleotide loop repair

16 Feb 2010

Abstract excerpt

BACKGROUND: The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsatellite instability (MSI) and the degree and type of MSI seem to be dependent on the MMR gene...

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PMID: 20160730
DOI: 10.1038/sj.bjc.6605531

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MutSβ exceeds MutSα in dinucleotide loop repairPMID 20160730Read ↗

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