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Article

MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.

The Journal of biological chemistry - 9 Apr 2010

Iyer Ravi R, Pluciennik Anna, Genschel Jochen, Tsai Miaw-Sheue, Beese Lorena S, Modrich Paul

Abstract excerpt

MutSbeta (MSH2-MSH3) mediates repair of insertion-deletion heterologies but also triggers triplet repeat expansions that cause neurological diseases. Like other DNA metabolic activities, MutSbeta interacts with proliferating cell nuclear antigen (PCNA) via a conserved motif (QXX(L/I)XXFF). We dem...

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Topics

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Share to Amino Acid Motifs
Share to Base Pair Mismatch
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to DNA Repair Enzymes

Share to Insecta

Share to MutL Proteins

Share to Proliferating Cell Nuclear Antigen

Source

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Identifiers

PMID: 20154325
DOI: 10.1074/jbc.M110.104125
PMCID: PMC2857047

Genes

PCNA
MSH3
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20154325-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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