Article
High frequency of integrase Q148R minority variants in HIV-infected patients naive of integrase inhibitors.
AIDS (London, England) - 27 Mar 2010
Charpentier Charlotte, Laureillard Didier, Piketty Christophe, Tisserand Pascaline, Batisse Dominique, Karmochkine Marina, Si-Mohamed Ali, Weiss Laurence
Abstract excerpt
BACKGROUND: Integrase positions 148 and 155 represent main determinants of resistance to integrase inhibitors. We assessed the prevalence of minority variants harboring such mutations in integrase-naive HIV-infected patients. METHODS: Two groups of patients were studied: 40 heavily antiretroviral...
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