Article
Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence.
Antimicrobial agents and chemotherapy - 1 May 2010
Jiang Sin-Sien, Lin Tzu-Yi, Wang Won-Bo, Liu Ming-Che, Hsueh Po-Ren, Liaw Shwu-Jen
Abstract excerpt
Proteus mirabilis is known to be highly resistant to the action of polymyxin B (PB). However, the mechanism underlying PB resistance is not clear. In this study, we used Tn5 transposon mutagenesis to identify genes that may affect PB resistance in P. mirabilis. Two genes, ugd and galU, which may encode UDP-glucose dehydrogenase (Ugd) and UDP-glucose pyrophosphorylase (GalU), respectively, were identified....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.