Article
Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion.
Antimicrobial agents and chemotherapy - 1 Apr 2010
Jiang Sin-Sien, Liu Ming-Che, Teng Lee-Jene, Wang Won-Bo, Hsueh Po-Ren, Liaw Shwu-Jen
Abstract excerpt
Proteus mirabilis is naturally resistant to polymyxin B (PB). To investigate the underlying mechanisms, Tn5 mutagenesis was performed, and a mutant exhibiting increased PB susceptibility was isolated. The mutant was found to have Tn5 inserted into the PpmrI (Proteus pmrI) gene, a gene which may encode a UDP-glucuronic acid decarboxylase. In other bacteria, pmrI belongs to the seven-gene pmrF operon, which is...
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