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Article

Copper affects virulence and diverse phenotypes of uropathogenic Proteus mirabilis.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Jun 2024

Huang Wei-Syuan, Lee Yuan-Ju, Wang Lu, Chen Hsuan-Hsuan, Chao Yueh-Jung, Cheng Vivien, Liaw Shwu-Jen

Abstract excerpt

BACKGROUND: Copper plays a role in urinary tract infection (UTI) and urinary copper content is increased during Proteus mirabilis UTI. We therefore investigated the effect of copper on uropathogenic P. mirabilis and the underlying mechanisms, focusing on the virulence associated aspects. METHODS: Mouse colonization, swarming/swimming assays, measurement of cell length, flagellin level and urease activity,...

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PMID: 38453541
DOI: 10.1016/j.jmii.2024.02.007

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