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Article

Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome

14 Feb 2022

Abstract excerpt

Significance Dravet syndrome (DS) is a severe childhood epileptic encephalopathy characterized by intractable seizures and comorbidities, including a high rate of premature mortality. DS is mainly caused by loss-of-function mutations of the Scn1a gene encoding sodium channel Na v 1.1 that is predominantly expressed in inhibitory parvalbumin-containing (PV) interneurons. Decreased Na v 1.1 impairs PV cell...

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PMID: 35165147
DOI: 10.1073/pnas.2022726119

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