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Article

Midline signaling regulates kidney positioning but not nephrogenesis through Shh.

Developmental biology - 15 Apr 2010

Tripathi Piyush, Guo Qiusha, Wang Yinqiu, Coussens Matthew, Liapis Helen, Jain Sanjay, Kuehn Michael R, Capecchi Mario R, Chen Feng

Abstract excerpt

The role of axial structures, especially the notochord, in metanephric kidney development has not been directly examined. Here, we showed that disruption of the notochord and floor plate by diphtheria toxin (DTA)-mediated cell ablation did not disrupt nephrogenesis, but resulted in kidney fusions...

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Identifiers

PMID: 20152829
DOI: 10.1016/j.ydbio.2010.02.007
PMCID: PMC2854326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20152829-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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