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Article

Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros.

Human molecular genetics - 1 Jul 2011

Burcklé Céline, Gaudé Helori-Mael, Vesque Christine, Silbermann Flora, Salomon Rémi, Jeanpierre Cécile, Antignac Corinne, Saunier Sophie, Schneider-Maunoury Sylvie

Abstract excerpt

Nephronophthisis is a hereditary nephropathy characterized by interstitial fibrosis and cyst formation. It is caused by mutations in NPHP genes encoding the ciliary proteins, nephrocystins. In this paper, we investigate the function of nephrocystin-4, the product of the nphp4 gene, in vivo by morpholino-mediated knockdown in zebrafish and in vitro in mammalian kidney cells. Depletion of nephrocystin-4 results in...

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PMID: 21498478
DOI: 10.1093/hmg/ddr164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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