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Article

p.Tyr365Cys change in factor VIII: haemophilia A, but not as we know it.

British journal of haematology - 1 Sept 2011

Bowyer Annette E, Goodeve Anne, Liesner Ri, Mumford Andrew D, Kitchen Steve, Makris Mike

Abstract excerpt

Haemophilia A is caused by a reduction in clotting factor VIII (FVIII). FVIII coagulant activity (FVIII:C) can be measured by three methods; the one-stage activated partial thromboplastin time-based clotting assay, the two-stage Xa generation-based clotting assay and the chromogenic Xa generation-based assay. The FVIII:C of most patients with haemophilia A are concordant regardless of the assay method employed....

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PMID: 21751985
DOI: 10.1111/j.1365-2141.2011.08688.x

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