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Article

A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene.

American journal of human genetics - 1 Apr 1991

Lekanne Deprez R H, Groen N A, van Biezen N A, Hagemeijer A, van Drunen E, Koper J W, Avezaat C J, Bootsma D, Zwarthoff E C

Abstract excerpt

Cytogenetic analysis of meningioma cells from one particular patient (MN32) displayed the stem-line karyo-type 45, XY, -1, 4p+, 22q-, 22q+, which thus had rearrangements of both chromosomes 22. The 22q+ marker appeared as a dicentric: 22 pter----q11::1p11----qter. The reciprocal product of this translocation has presumably been lost because it lacked a centromere. The 22q- chromosome also appeared to have lost...

Topics

Alleles
Animals
Chromosome Banding
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 4
Cricetinae
DNA
Genes, Tumor Suppressor
Genetic Linkage
Genetic Markers
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hybrid Cells

Meningioma

Translocation, Genetic

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 2014801
PMCID: PMC1682947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2014801-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene.PMID 2014801Read ↗

Deletion mapping of the long arm of chromosome 22 in human meningiomasSemantic proximity Read ↗

Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotype.Semantic proximity Read ↗

Chromosomal deletions in anaplastic meningiomas suggest multiple regions outside chromosome 22 as important in tumor progressionSemantic proximity Read ↗

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Familial meningioma is not allelic to neurofibromatosis 2.Semantic proximity Read ↗

Frequent loss of 1p32 region but no mutation of the p18 tumor suppressor gene in meningiomas.Semantic proximity Read ↗

Loss of chromosome 22 and absence of NF2 gene mutation in a case of multiple meningiomas.Semantic proximity Read ↗

Evidence for an ependymoma tumour suppressor gene in chromosome region 22pter-22q11.2.Semantic proximity Read ↗

Analysis of chromosome 22 loci in meningioma. Alterations in the leukemia inhibitory factor (LIF) locus.Semantic proximity Read ↗

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Chromosome 22 heterozygosity is retained in most hyperdiploid and pseudodiploid meningiomas.Semantic proximity Read ↗

Molecular analysis of a myxoid chondrosarcoma with rearrangements of chromosomes 10 and 22.Semantic proximity Read ↗

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