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Article

Rab7A Is Required for Efficient Production of Infectious HIV-1

3 Nov 2011

Abstract excerpt

Retroviruses take advantage of cellular trafficking machineries to assemble and release new infectious particles. Rab proteins regulate specific steps in intracellular membrane trafficking by recruiting tethering, docking and fusion factors, as well as the actin- and microtubule-based motor proteins that facilitate vesicle traffic. Using virological tests and RNA interference targeting Rab proteins, we...

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PMID: 22072966
DOI: 10.1371/journal.ppat.1002347

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