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Article

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.

Pharmacogenomics - 1 Feb 2014

Brown Chad C, Havener Tammy M, Medina Marisa W, Jack John R, Krauss Ronald M, McLeod Howard L, Motsinger-Reif Alison A

Abstract excerpt

AIM: Association mapping with lymphoblastoid cell lines (LCLs) is a promising approach in pharmacogenomics research, and in the current study we utilized LCLs to perform association mapping for 29 chemotherapy drugs. MATERIALS & METHODS: Currently, we use LCLs to perform genome-wide association mapping of the cytotoxic response of 520 European-Americans to 29 different anticancer drugs; the largest LCL study to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24444404
DOI: 10.2217/pgs.13.213
PMCID: PMC4055088

Genes

CHN2
HDAC4
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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