Article
DNA methylation changes in gastrointestinal disease.
Journal of gastroenterology - 1 Nov 2002
Toyota Minoru, Itoh Fumio, Kikuchi Takefumi, Satoh Ayumi, Obata Toshiro, Suzuki Hiromu, Ishii Suguru, Endo Takao, Tokino Takashi, Imai Kohzoh
Abstract excerpt
DNA methylation of the 5' region of genes is often associated with gene silencing in X-chromosome inactivation and imprinting. Recent studies have indicated that altered DNA methylation plays a role in the inactivation of multiple tumor suppressor genes and DNA repair genes such as p16INK4A and hMLH1. Colorectal adenomas have a relatively high frequency of methylation, and aberrant methylation is an early event...
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