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Article

Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 May 2008

Yager Phoebe H, You Zerong, Qin Tao, Kim Hyung-Hwan, Takahashi Kazue, Ezekowitz Alan B, Stahl Gregory L, Carroll Michael C, Whalen Michael J

Abstract excerpt

Mannose binding lectin (MBL) initiates complement activation and exacerbates tissue damage after systemic ischemia/reperfusion. We tested the hypothesis that MBL activates complement and worsens outcome using two levels of controlled cortical impact (CCI) in mice. After moderate CCI (0.6 mm depth), MBL immunostaining was detected on injured endothelial cells of wild-type (WT) mice and C3d was detected in MBL KO...

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Identifiers

PMID: 18183030
DOI: 10.1038/sj.jcbfm.9600605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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