Article
Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip.
Pharmacogenomics - 1 Feb 2010
Cuyàs Elisabet, Olano-Martín Estibaliz, Khymenets Olha, Hernández Lorena, Jofre-Monseny Laia, Grandoso Laura, Tejedor Diego, Martínez Antonio, Farré Magí, de la Torre Rafael
Abstract excerpt
AIMS: Differences in adverse drug reactions can be explained by genetic variations, especially if they determine the expression of certain protein effectors and/or drug-metabolizing enzymes. Over the last decade, several tests screening for the most frequent polymorphisms in drug-metabolizing enzymes have been marketed for research and diagnostic purposes. The aim of this study was to assess the suitability of...
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