Article
CYP17 (T-34C) and CYP19 (Trp39Arg) polymorphisms and their cooperative effects on breast cancer susceptibility.
In vivo (Athens, Greece) - 1 Jan 2000
Tüzüner Bora M, Oztürk Tülin, Kisakesen Halil I, Ilvan Sennur, Zerrin Calay, Oztürk Oğuz, Isbir Turgay
Abstract excerpt
BACKGROUND: Breast cancer is the commonest cancer among women in industrialized countries. Most sporadic breast carcinomas are likely to be caused by low-penetrance genes. Genes encoding enzymes involved in estrogen and carcinogen metabolism are among these low-penetrance genes. In this study, for the first time the T/C (A1/A2) polymorphism at the 5' untranslated region (UTR) of CYP17 and the Arg/Trp (T/C)...
Topics
- Adenocarcinoma, Mucinous
- Adult
- Aged
- Aged, 80 and over
- Aromatase
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Carcinoma, Medullary
- Case-Control Studies
- DNA, Neoplasm