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Article

Selective targeting of radiation-resistant tumor-initiating cells

3 Feb 2010

Abstract excerpt

Tumor-initiating cells (TICs) have been shown both experimentally and clinically to be resistant to radiation and chemotherapy, potentially resulting in residual disease that can lead to recurrence. In this study, we demonstrate that TICs isolated from p53 null mouse mammary tumors repair DNA damage following in vivo ionizing radiation more efficiently than the bulk of the tumor cells. Down-regulation of...

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PMID: 20133717
DOI: 10.1073/pnas.0910179107

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