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Article

WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells

4 Jan 2007

Abstract excerpt

Recent studies have identified a subpopulation of highly tumorigenic cells with stem/progenitor cell properties from human breast cancers, and it has been suggested that stem/progenitor cells, which remain after breast cancer therapy, may give rise to recurrent disease. We hypothesized that progenitor cells are resistant to radiation, a component of conventional breast cancer therapy, and that that resistance is...

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PMID: 17202265
DOI: 10.1073/pnas.0606599104

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