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Article

Wnt/β-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line

17 Jan 2007

Abstract excerpt

The COMMA-Dbeta-geo cell line has been shown to contain a permanent subpopulation of progenitor cells that are enriched in outgrowth potential. Using the COMMA-Dbeta-geo cell line as a model, we sought to study the radioresistance of mammary progenitor cells. Using the putative progenitor cell marker stem cell antigen 1 (Sca1), we were able to isolate a discrete subpopulation of Sca1(+) multipotent cells from the...

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PMID: 17227796
DOI: 10.1242/jcs.03348

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