PERSPECTIVES ON CLASSIC ARTICLES: Metastasis Suppressor Genes

Abstract excerpt

The metastasis suppressor gene field was launched in 1988 with the publication of an article in JNCI identifying nm23 (1). Despite the devastating consequences of tumor metastasis, little of its molecular regulation was known in 1988. Most studies at that time focused on the acquisition of traits, principally those involved in invasion. The instability of metastatic cell lines in terms of their behavior, gene...