Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application

Abstract excerpt

Clinically and experimentally, primary tumor formation and metastasis are distinct processes — locally growing tumors can progress without the development of metastases. This observation prompted the hypothesis that the molecular processes regulating tumorigenicity and metastasis are distinguishable and could be targeted therapeutically. During the process of transformation and subsequent progression to a...

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