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Article

Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma.

International journal of oncology - 1 Mar 2010

Stefancikova Lenka, Moulis Mojmir, Fabian Pavel, Ravcukova Barbora, Vasova Ingrid, Muzik Jan, Malcikova Jitka, Falkova Iva, Slovackova Jana, Smardova Jana

Abstract excerpt

Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also...

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Share to Cell Line, Tumor
Share to Cyclin D1
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Lymphoma, Mantle-Cell

Share to Prognosis

Share to Translocation, Genetic

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 20126990
DOI: 10.3892/ijo_00000545

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20126990-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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