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p53 is associated with high‐risk and pinpointsTP53missense mutations in mantle cell lymphoma

4 Aug 2020

Abstract excerpt

Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely implemented in...

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PMID: 32748433
DOI: 10.1111/bjh.17023

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