Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.

Mechanisms of ageing and development - 1 Oct 2009

Nebel Almut, Flachsbart Friederike, Till Andreas, Caliebe Amke, Blanché Hélène, Arlt Alexander, Häsler Robert, Jacobs Gunnar, Kleindorp Rabea, Franke Andre, Shen Binghui, Nikolaus Susanna, Krawczak Michael, Rosenstiel Philip, Schreiber Stefan

Abstract excerpt

Human longevity is heritable with a genetic component of 25-32%. Variation in genes regulating the levels of somatic maintenance and DNA repair functions is thought to modulate the aging process and to contribute to survival at advanced age. We tested 92 non-synonymous SNPs in 49 DNA repair genes for a possible association with longevity in a sample of 395 German centenarians and 411 controls. The obtained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Enzymes
Share to Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germany

Share to Jurkat Cells

Share to Logistic Models

Share to Longevity

Share to TCF Transcription Factors

Share to Up-Regulation

Source

Identifiers

PMID: 19698732
DOI: 10.1016/j.mad.2009.08.004

Genes

EXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.PMID 19698732Read ↗

Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis.Semantic proximity Read ↗

Elevated EXO1 expression is associated with breast carcinogenesis and poor prognosisSemantic proximity Read ↗

Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity.Semantic proximity Read ↗

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer.Semantic proximity Read ↗

Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan.Semantic proximity Read ↗

Exonuclease 1 (EXO1) gene variation and melanoma risk.Semantic proximity Read ↗

Variation analysis of EXO1 gene in Chinese patients with premature ovarian failure.Semantic proximity Read ↗

Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan.Semantic proximity Read ↗

The genetics of exceptional longevity: Insights from centenarians.Semantic proximity Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Associations between Nine Polymorphisms in EXO1 and Cancer Susceptibility: A Systematic Review and Meta-Analysis of 39 Case-control Studies.Semantic proximity Read ↗

The exonuclease 1 Glu589Lys gene polymorphism and cancer susceptibility: evidence based on a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.