Article
The effects of two polymorphisms on p21cip1 function and their association with Alzheimer's disease in a population of European descent.
PloS one - 1 Jan 2015
Yates Sharon C, Zafar Amen, Rabai Erzsebet M, Foxall James B, Nagy Sheila, Morrison Karen E, Clarke Carl, Esiri Margaret M, Christie Sharon, Smith A David, Nagy Zsuzsanna
Abstract excerpt
With the exception of ApoE4, genome-wide association studies have failed to identify strong genetic risk factors for late-onset Alzheimer's disease, despite strong evidence of heritability, suggesting that many low penetrance genes may be involved. Additionally, the nature of the identified genetic risk factors and their relation to disease pathology is also largely obscure. Previous studies have found that a...
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