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Article

RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43.

Journal of bacteriology - 1 Jun 2010

Cheng H Y, Chen Y S, Wu C Y, Chang H Y, Lai Y C, Peng H L

Abstract excerpt

Sequence analysis of the large virulence plasmid pLVPK in Klebsiella pneumoniae CG43 revealed the presence of another mucoid factor encoding gene rmpA besides rmpA2. Promoter activity measurement indicated that the deletion of rmpA reduced K2 capsular polysaccharide (CPS) biosynthesis, resulting in decreased colony mucoidy and virulence in mice. Introduction of a multicopy plasmid carrying rmpA restored CPS...

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Identifiers

PMID: 20382770
DOI: 10.1128/JB.00031-10
PMCID: PMC2901686

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Source receipt: pubmed, retrieved 7 Sept 2026.

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