Article
Prediction of KIT mutation in gastrointestinal stromal tumors by the immunoprofile of the tumor cells.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Jan 2010
Chou Chu-Chung, Chou Ming-Jen, Tzen Chin-Yuan
Abstract excerpt
BACKGROUND/PURPOSE: Human KIT protooncogene is the cellular homolog of v-kit from the Hardy-Zuckerman 4 feline sarcoma virus, and encodes a 145-kDa type III tyrosine kinase growth factor receptor that is often mutated in gastrointestinal stromal tumors (GIST). Standardized mutation analysis is not available in many countries; therefore, we aimed to determine if the presence of KIT mutation in GIST can be...
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