Article
Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome.
BMC genomics - 1 Feb 2010
Lopes Alexandra M, Burgoyne Paul S, Ojarikre Andrew, Bauer Julien, Sargent Carole A, Amorim António, Affara Nabeel A
Abstract excerpt
BACKGROUND: X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which escape X inactivation, and thus are expressed at higher levels in females, is very small. However this hypothesis has never been tested and only a small number of genes...
Topics
- Alleles
- Animals
- Female
- Gene Expression Profiling
- Gene Regulatory Networks
- Genes, X-Linked
- Mice
- Oligonucleotide Array Sequence Analysis
- Transcription, Genetic
- Turner Syndrome
- X Chromosome
- X Chromosome Inactivation