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Article

Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease.

Hemoglobin - 1 Jan 2010

Al-Saqladi Abdul-Wahab M, Harper Greg, Delpisheh Ali, Fijnvandraat Karin, Bin-Gadeem Hassan A, Brabin Bernard J

Abstract excerpt

The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen. The homozygous TT genotype for MTHFR C677T was present in 2% (2/102), and heterozygous CT in 10.8% (11/102), giving an allele frequency of...

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Share to Anemia, Sickle Cell
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 20113291
DOI: 10.3109/09687630903554111

Genes

MTHFR

Variants

Provenance

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Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease.PMID 20113291Read ↗

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