Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequency of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients.

American journal of hematology - 1 Apr 2001

Adekile A D, Kutlar F, Haider M Z, Kutlar A

Abstract excerpt

Sickle cell disease (SCD) is relatively mild among Kuwaiti Arabs. However, an atypical subset of patients exists with frequent, severe vaso-occlusive crisis and osteonecrosis. The thermolabile variant of MTHFR, resulting from a C-->T mutation at nucleotide 677, has been shown to be associated wit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Femur Head Necrosis
Share to Fetal Hemoglobin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hospitalization

Share to Hyperhomocysteinemia

Share to Kuwait

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Thrombophilia

Source

Identifiers

PMID: 11279637
DOI: 10.1002/ajh.1055

Genes

MTHFR
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11279637-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients.PMID 11279637Read ↗

Prevalence of the mutation C677 --> T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil.Semantic proximity Read ↗

Frequency of methylenetetrahydrofolate reductase C677T polymorphism in patients with cardiovascular disease in Eastern Saudi Arabia.Semantic proximity Read ↗

THE METHYLENE TETRAHYDROFOLATE REDUCTASE (C677T) MUTATION AS A POTENTIAL RISK FACTOR FOR AVASCULAR NECROSIS IN SICKLE CELL DISEASESemantic proximity Read ↗

HLA-DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head.Semantic proximity Read ↗

Analysis of the 677 C→T Mutation of the Methylenetetrahydrofolate Reductase Gene in Different Ethnic GroupsSemantic proximity Read ↗

Pattern of bone mineral density in sickle cell disease patients with the high-Hb F phenotype.Semantic proximity Read ↗

Morbidity, β <sup>s</sup> Haplotype and α-Globin Gene Patterns among Sickle Cell Anemia Patients in KuwaitSemantic proximity Read ↗

Association of the methylenetetrahydrofolate reductase A1298C but not the C677T single nucleotide polymorphism with sickle cell disease in Bahrain.Semantic proximity Read ↗

The 677C-->T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head.Semantic proximity Read ↗

The Prevalence of Factor V Leiden (G1691A) and Methylenetetrahydrofolate Reductase C677T Mutations in Sickle Cell Disease in Western India.Semantic proximity Read ↗

Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease.Semantic proximity Read ↗

T-786C polymorphism of the endothelial nitric oxide synthase gene and neuralgia-inducing cavitational osteonecrosis of the jaws.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.