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Article

Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease.

Journal of pediatric hematology/oncology - 1 Jan 2000

Balasa V V, Gruppo R A, Gartside P S, Kalinyak K A

Abstract excerpt

Recently, a mild to moderate elevation in the plasma homocysteine (Hcy) level has been found to be an important risk factor for stroke. Homozygosity for a common mutation (C677T) in the gene encoding for the enzyme methylenetetrahydrofolate reductase (MTHFR) involved in Hcy metabolism has been associated with increased levels of Hcy. To determine the role of hyperhomocysteinemia in the pathogenesis of stroke in...

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Share to Anemia, Sickle Cell
Share to beta-Thalassemia
Share to Hemoglobin, Sickle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Point Mutation

Share to Stroke

Source

Identifiers

PMID: 10524453
DOI: 10.1097/00043426-199909000-00011

Genes

SCD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease.PMID 10524453Read ↗

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MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children With Sickle Cell Disease.Semantic proximity Read ↗

Frequency of the MTHFR C677T polymorphism in Yemeni children with sickle cell disease.Semantic proximity Read ↗

Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell disease.Semantic proximity Read ↗

Hyperhomocysteinaemia in a young woman presenting with stroke, associated with methylene tetrahydrofolate reductase C677T homozygosity.Semantic proximity Read ↗

Association of the methylenetetrahydrofolate reductase A1298C but not the C677T single nucleotide polymorphism with sickle cell disease in Bahrain.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase C677T genotype and stroke.Semantic proximity Read ↗

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