Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell disease.

Journal of pediatric hematology/oncology - 1 Jan 2000

Balasa Vinod V, Kalinyak Karen A, Bean Judy A, Stroop Davis, Gruppo Ralph A

Abstract excerpt

Elevated plasma homocysteine levels have been shown to be a risk factor for endothelial cell damage and thrombosis, which are implicated in sickle cell disease (SCD)-related vaso-occlusion. The aim of this study was to determine the prevalence of hyperhomocysteinemia in SCD. Fasting and postmethionine load (PML) homocysteine, red cell folate, and the MTHFR C677T mutation were determined in 77 patients with SCD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homocysteine

Share to Hyperhomocysteinemia

Share to Methionine

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Pyridoxine

Share to Vitamin B 12

Source

Identifiers

PMID: 12142786
DOI: 10.1097/00043426-200206000-00010

Genes

SCD
PML
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell disease.PMID 12142786Read ↗

Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.Semantic proximity Read ↗

Homocysteine metabolism.Semantic proximity Read ↗

Clinical chemistry and molecular biology of homocysteine metabolism: an update.Semantic proximity Read ↗

MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children With Sickle Cell Disease.Semantic proximity Read ↗

Stroke in young patients with hyperhomocysteinemia due to cystathionine beta-synthase deficiency.Semantic proximity Read ↗

Plasma homocysteine concentration in children with chronic renal failure.Semantic proximity Read ↗

Homocysteine: evidence for a causal relationship with cardiovascular disease.Semantic proximity Read ↗

Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children.Semantic proximity Read ↗

The Link Between Hyperhomocysteinemia and HypomethylationSemantic proximity Read ↗

The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with retinal artery occlusion.Semantic proximity Read ↗

Homocysteine, coagulation, platelet function, and thrombosis.Semantic proximity Read ↗

Occurrence of hyperhomocysteinaemia in cardiovascular, haematology and nephrology patients: contribution of folate deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.