Article
Dichotomous relationship between DNA reactivity and the induction of sister chromatid exchanges in vivo and in vitro.
Mutation research - 9 Jun 1997
Labbauf A, Klopman G, Rosenkranz H S
Abstract excerpt
Structural analyses of the determinants associated with the induction of bone marrow sister chromatid exchanges in mice indicate that the phenomenon is based on an electrophilic attack on DNA. In that respect this phenomenon is different from the basis of the induction of SCE in cultured cells or...
Topics
- Algorithms
- Animals
- Bone Marrow
- Carcinogens
- Cells, Cultured
- Chromosome Aberrations
- Cytochrome P-450 Enzyme Inhibitors
- DNA
- Humans
- Information Systems
- Mice
- Micronuclei, Chromosome-Defective
- Mutagens
- Mutation
- Sister Chromatid Exchange
- Software
- Structure-Activity Relationship
- Xenobiotics