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Article

Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.

Circulation research - 5 Mar 2010

Navedo Manuel F, Cheng Edward P, Yuan Can, Votaw Scott, Molkentin Jeffery D, Scott John D, Santana Luis F

Abstract excerpt

RATIONALE: L-Type (Cav1.2) Ca(2+) channels are critical regulators of muscle and neural function. Although Cav1.2 channel activity varies regionally, little is known about the mechanisms underlying this heterogeneity. OBJECTIVE: To test the hypothesis that Cav1.2 channels can gate coordinately. METHODS AND RESULTS: We used optical and electrophysiological approaches to record Cav1.2 channel activity in cardiac,...

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Source

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Identifiers

PMID: 20110531
DOI: 10.1161/CIRCRESAHA.109.213363
PMCID: PMC2834417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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