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Article

L-type Ca2+ channel function during Timothy syndrome.

Trends in cardiovascular medicine - 1 Apr 2012

Dixon Rose E, Cheng Edward P, Mercado Jose L, Santana Luis F

Abstract excerpt

Voltage-gated, dihydropyridine-sensitive L-type Ca(2+) channels are multimeric proteins composed of a pore-forming transmembrane α(1) subunit (Ca(v)1.2) and accessory β, α(2)δ, and γ subunits. Ca(2+) entry via Ca(v)1.2 channels shapes the action potential (AP) of cardiac myocytes and is required...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22999068
DOI: 10.1016/j.tcm.2012.06.015
PMCID: PMC3640256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22999068-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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L-type Ca2+ channel function during Timothy syndrome.PMID 22999068Read ↗

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Current updates on arrhythmia within Timothy syndrome: genetics, mechanisms and therapeutics.Semantic proximity Read ↗

Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.Semantic proximity Read ↗

Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.Semantic proximity Read ↗

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.Semantic proximity Read ↗

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Introduction into Ca(v)2.1 of the homologous mutation of Ca(v)1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca(2+) channel.Semantic proximity Read ↗

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