Article
Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2012
Dixon Rose E, Yuan Can, Cheng Edward P, Navedo Manuel F, Santana Luis F
Abstract excerpt
Ca(2+) influx via L-type Ca(v)1.2 channels is essential for multiple physiological processes, including gene expression, excitability, and contraction. Amplification of the Ca(2+) signals produced by the opening of these channels is a hallmark of many intracellular signaling cascades, including excitation-contraction coupling in heart. Using optogenetic approaches, we discovered that Ca(v)1.2 channels form...
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