Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.

The American journal of pathology - 1 Mar 2010

Rutkowski Joseph M, Markhus Carl Erik, Gyenge Christina C, Alitalo Kari, Wiig Helge, Swartz Melody A

Abstract excerpt

Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse models of primary lymphedema, the Chy mouse and the K14-VEGFR-3-Ig mouse, both la...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Collagen
Share to Dermis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Fluid

Share to Lipid Metabolism

Share to Lymphedema

Share to Pressure

Share to Vascular Endothelial Growth Factor Receptor-3

Source

Open in PubMed Open full text

Identifiers

PMID: 20110415
DOI: 10.2353/ajpath.2010.090733
PMCID: PMC2832135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20110415-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.PMID 20110415Read ↗

Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.Semantic proximity Read ↗

Chy-3 mice are Vegfc haploinsufficient and exhibit defective dermal superficial to deep lymphatic transition and dermal lymphatic hypoplasia.Semantic proximity Read ↗

Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and FibrosisSemantic proximity Read ↗

Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema.Semantic proximity Read ↗

Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedemaSemantic proximity Read ↗

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.Semantic proximity Read ↗

Heterozygous mutation of <i>Vegfr3</i> decreases renal lymphatics but is dispensable for renal functionSemantic proximity Read ↗

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.Semantic proximity Read ↗

Heterozygous Mutation of Vegfr3 Reduces Renal Lymphatics without Renal Dysfunction.Semantic proximity Read ↗

Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration.Semantic proximity Read ↗

Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothoraxSemantic proximity Read ↗

Molecular regulation of lymphangiogenesis and targets for tissue oedemaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.