Article
Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2013
Markhus C E, Karlsen T V, Wagner Marek, Wagner M, Svendsen Ø S, Tenstad O, Alitalo K, Wiig H
Abstract excerpt
OBJECTIVE: The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation in the interstitium occurring in lymphedema results in...
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