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Article

Calnexin is essential for rhodopsin maturation, Ca2+ regulation, and photoreceptor cell survival.

Neuron - 19 Jan 2006

Rosenbaum Erica E, Hardie Roger C, Colley Nansi J

Abstract excerpt

In sensory neurons, successful maturation of signaling molecules and regulation of Ca2+ are essential for cell function and survival. Here, we demonstrate a multifunctional role for calnexin as both a molecular chaperone uniquely required for rhodopsin maturation and a regulator of Ca2+ that enters photoreceptor cells during light stimulation. Mutations in Drosophila calnexin lead to severe defects in rhodopsin...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16423697
DOI: 10.1016/j.neuron.2005.12.011
PMCID: PMC3414428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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