Article
Identification and sequence analysis of the gene mutated in the conditionally lethal outer membrane permeability mutant SS-C of Salmonella typhimurium.
The EMBO journal - 1 Apr 1991
Hirvas L, Koski P, Vaara M
Abstract excerpt
The biosynthesis and structure-function relationships of the enterobacterial outer membrane are subjects of current intensive research. We have previously described the antibiotic supersensitive SS-C mutant (SH7622) of Salmonella typhimurium and shown that its outer membrane permeability barrier against hydrophobic antibiotics is severely defective. In this study, we show that this mutant is heat-sensitive,...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Base Sequence
- Cell Membrane
- Cell Membrane Permeability
- Cloning, Molecular
- Genes, Bacterial
- Genes, Lethal
- Microbial Sensitivity Tests
- Molecular Sequence Data