Article
An ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin.
Antimicrobial agents and chemotherapy - 1 May 2009
Becker Petra, Hakenbeck Regine, Henrich Bernhard
Abstract excerpt
Vancoresmycin is a novel tetramic acid antibiotic, probably interfering with functions of the cytoplasmic membrane. To investigate its mode of action, mutants of Streptococcus pneumoniae exhibiting reduced susceptibility to vancoresmycin were isolated at a low frequency. Four of them were further examined and showed similar pleiotropic phenotypes, including reduced growth rate, early autolysis, and chain...
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