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Article

An ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin.

Antimicrobial agents and chemotherapy - 1 May 2009

Becker Petra, Hakenbeck Regine, Henrich Bernhard

Abstract excerpt

Vancoresmycin is a novel tetramic acid antibiotic, probably interfering with functions of the cytoplasmic membrane. To investigate its mode of action, mutants of Streptococcus pneumoniae exhibiting reduced susceptibility to vancoresmycin were isolated at a low frequency. Four of them were further examined and showed similar pleiotropic phenotypes, including reduced growth rate, early autolysis, and chain...

Topics

ATP-Binding Cassette Transporters
Anti-Bacterial Agents
Bacitracin
Bacterial Proteins
Drug Resistance, Bacterial
Gene Expression Profiling
Humans
Membrane Transport Proteins
Microbial Sensitivity Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Array Sequence Analysis

Pyrrolidinones

Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 19273682
DOI: 10.1128/AAC.01485-08
PMCID: PMC2681518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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