Article
Overexpression of ornithine aminotransferase: consequences on amino acid homeostasis.
The British journal of nutrition - 1 Mar 2009
Ventura Gabrielle, De Bandt Jean-Pascal, Segaud Frédéric, Perret Christine, Robic Daniel, Levillain Olivier, Le Plenier Servane, Godard Cécile, Cynober Luc, Moinard Christophe
Abstract excerpt
Ornithine aminotransferase (OAT) is a reversible enzyme expressed mainly in the liver, kidney and intestine. OAT controls the interconversion of ornithine into glutamate semi-aldehyde, and is therefore involved in the metabolism of arginine and glutamine which play a major role in N homeostasis. We hypothesised that OAT could be a limiting step in glutamine-arginine interconversion. To study the contribution of...
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