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Article

Structural basis for unfolding pathway-dependent stability of proteins: vectorial unfolding versus global unfolding.

Protein science : a publication of the Protein Society - 1 Apr 2010

Yagawa Keisuke, Yamano Koji, Oguro Takaomi, Maeda Masahiro, Sato Takehiro, Momose Takaki, Kawano Shin, Endo Toshiya

Abstract excerpt

Point mutations in proteins can have different effects on protein stability depending on the mechanism of unfolding. In the most interesting case of I27, the Ig-like module of the muscle protein titin, one point mutation (Y9P) yields opposite effects on protein stability during denaturant-induced...

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Identifiers

PMID: 20095049
DOI: 10.1002/pro.346
PMCID: PMC2867010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20095049-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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