Article
The Y9P Variant of the Titin I27 Module: Structural Determinants of Its Revisited Nanomechanics.
Structure (London, England : 1993) - 5 Apr 2016
Oroz Javier, Bruix Marta, Laurents Douglas V, Galera-Prat Albert, Schönfelder Jörg, Cañada Francisco Javier, Carrión-Vázquez Mariano
Abstract excerpt
The titin I27 module from human cardiac titin has become a standard in protein nanomechanics. A proline-scanning study of its mechanical clamp found three mechanically hypomorphic mutants and a paradoxically hypermorphic mutant (I27Y9P). Both types of mutants have been commonly used as substrates of several protein unfoldase machineries in studies relating protein mechanostability to translocation or degradation...
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