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Article

Detection of single nucleotide polymorphisms using a DNA Holliday junction nanoswitch--a high-throughput fluorescence lifetime assay.

Molecular bioSystems - 1 Feb 2010

McGuinness Colin D, Nishimura Mira K Y, Keszenman-Pereyra David, Dickinson Paul, Campbell Colin J, Bachmann Till T, Ghazal Peter, Crain Jason

Abstract excerpt

We report a simple DNA sensor device, using a combination of binding and conformational switching, capable of rapid detection of specific single nucleotide polymorphisms in an unlabelled nucleic acid target sequence. The detection is demonstrated using fluorescence lifetime measurements in a high-throughput micro plate reader instrument based on the time-correlated single-photon counting technique. The sensor...

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PMID: 20094658
DOI: 10.1039/b913455g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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