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Article

Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha.

The American journal of pathology - 1 Mar 2010

Ghosh Sanjukta, Hoenerhoff Mark J, Clayton Natasha, Myers Page, Stumpo Deborah J, Maronpot Robert R, Blackshear Perry J

Abstract excerpt

Inflammation may play a role in the etiology of both degenerative and rheumatic cardiac valve diseases. We report here that mice deficient in tristetraprolin (TTP), a protein with known anti-inflammatory functions, develop severe left-sided cardiac valvulitis. TTP is an mRNA binding protein that inhibits inflammation by destabilizing the mRNA encoding tumor necrosis factor alpha (TNF). This leads in turn to a...

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Identifiers

PMID: 20093488
DOI: 10.2353/ajpath.2010.090498
PMCID: PMC2832167

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha.PMID 20093488Read ↗

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