Article
Proteome changes in CaMKIIδC-overexpressing cardiac myocytes.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000
Schott Peter, Jacobshagen Claudius, Köhler Jürgen, Seidler Tim, Asif Abdul R, Dihazi Hassan, Hasenfuss Gerd, Maier Lars S
Abstract excerpt
Recent studies have demonstrated that the expression as well as the activity of Ca/calmodulin-dependent protein kinase IIδ(C) (CaMKIIδ(C)) is increased in heart failure. Transgenic overexpression of CaMKIIδ(C) in mouse hearts results in severe dilated cardiomyopathy. So far, little is known about CaMKIIδ(C)-induced changes in gene expression and proteome alteration. We hypothesize that proteome changes similar to...
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