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Article

Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition.

Circulation research - 18 Oct 2002

Hahn Harvey S, Yussman Martin G, Toyokawa Tsuyoshi, Marreez Yehia, Barrett Thomas J, Hilty K Chad, Osinska Hanna, Robbins Jeffrey, Dorn Gerald W

Abstract excerpt

To delineate the in vivo cardiac functions requiring normal delta protein kinase C (PKC) activity, we pursued loss-of-function through transgenic expression of a deltaPKC-specific translocation inhibitor protein fragment, deltaV1, in mouse hearts. Initial results using the mouse alpha-myosin heavy chain (alphaMHC) promoter resulted in a lethal heart failure phenotype. Viable deltaV1 mice were therefore obtained...

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PMID: 12386152
DOI: 10.1161/01.res.0000037091.64492.69

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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